Duration: 3h

The PRO instrument: health questionnaires. What should be measured with this type of instrument from the patient's perspective? Defining Health-Related Quality of Life (HRQoL) and its determinants.
Different types of PRO instruments. Different types of response scales. Advantages and disadvantages of each of them.

Evaluation of a PRO instrument: validity; reliability; content validity; construct validity; criterion validity; test-retest or intra-interviewer reliability; Internal consistency; inter-interviewer variability.