Modulation of Amyloid Lipid Formation by Lipid Membranes

11 Outubro 2017, 09:30 • Ana Isabel Abrantes Coutinho

Introduction to protein misfolding diseases. Kinetics of amyloid fibril formation.
Soluble pre-fibrillar oligomers are the primary cytotoxic species.
Dual role of biological membranes: catalysts of amyloid fibril formation and targets of cytotoxic species.
Analytical challenges in studying soluble pre-fibrillar oligomers.
Physico-chemical variability of the cellular lipid environment.