Sumários
Parkinson's Disease
17 Novembro 2021, 09:30 • Cláudio Emanuel Moreira Gomes
Parkinson's Disease. Characteristics and risk factors; Molecular aspects: alpha-sinuclein protein and its neurobiology and dissemination of toxic aggregates. PARK7, PArkin, LRRK2, PINK1. Cellular processes of pathogenesis in PD. Biomarkers and possible therapeutic targets.
Alzheimer's Disease - Biomarkers, models and therapies (cont.)
10 Novembro 2021, 11:30 • Cláudio Emanuel Moreira Gomes
Alzheimer's Disease - Biomarkers, models and therapies (cont.). Discussion of recente literature reporting novel methods/biomarkers for AD staging. Research Seminar: Experimental models in neurodegeneration (Prof. A Fernandes, iMED / FF-UL).
Alzheimer's Disease - Biomarkers, moldes and therapies
10 Novembro 2021, 09:30 • Cláudio Emanuel Moreira Gomes
Alzheimer's Disease - Biomarkers, models and therapies. The challenge of biomarkers and imaging methods for AD. Therapeutic approaches and the challenge of drug development: the case of aducanumab - molecular basis, advantages and limitations, Experimental models in neurodegeneration. General perspectives on different models: purified proteins, cellular models, 3D cell cultures, studies in species, animal models; benefits and limitations.
Alzheimer's Disease - Molecular Basis (cont.)
3 Novembro 2021, 11:30 • Cláudio Emanuel Moreira Gomes
Alzheimer's Disease - Molecular Basis (cont.). Discussion of the amyloid cascade hypothesis versus published findings. Biological regulation of protein aggregation. Research seminar: Extracellular chaperones targeting amyloids in the brain (C.M. Gomes, FCUL)
Alzheimer's Disease - Molecular Basis
3 Novembro 2021, 09:30 • Cláudio Emanuel Moreira Gomes
Alzheimer's Disease - Molecular Basis. Characteristics and risk factors; Molecular aspects: amyloid-beta protein and Tau, neurobiology and the formation / dissemination of toxic aggregates. APP, Secretases, Presinilin.Pathogenic cellular processes in AD. Structural Biology of Alzheimer's disease. Familial AD.