Sumários
Journal Club
10 Janeiro 2020, 14:30 • Patricia Beldade
Student led journal clubs based on review paper: Evolution and Public Health 1 - groups 1 and 2. Discussion of project topics.
Virus and vaccines.
10 Janeiro 2020, 13:00 • Patricia Beldade
Virus and veccines. Properties, types, and examples of virus. The flu virus. Influenza in medicine and society. Flu types, flu genome and flu ecology. Viral life cycle. Generating genetic diversity in flu virus: mutation and reassortment. Seasonal and pandamic flu. Vaccination for seasonal flu. Lecture by invited faculty, Maria João Amorim (IGC).
Our microbes: friends and foes.
9 Janeiro 2020, 14:00 • Patricia Beldade
Our microbes: friends and foes. Part 1: Evolution of gut microbiota, Differences between studies in vivo, in vitro, in natura. Colonization of and persistance in the mammalian gut. Mutation rates and mutation effects. Predictability of evolution. Part 2: Evolution of antibiotic resistance. Costs of resistance and epistasis. Lecture by invited professor, Isabel Gordo (IGC).
Population Genetics and disease alleles.
9 Janeiro 2020, 13:00 • Patricia Beldade
Hardy-Weinberg equlibrium: definition, assumptions, assessment. Examples of effects of mutation, migration, selection, drift, and non-random mating on the frequency and distribution of disease alleles.
Overview and example of Evolutionary Medicine
8 Janeiro 2020, 14:00 • Patricia Beldade
Overview of Evolutionary Medicine. How it differs from clinical genetics. Disease symptoms as unhealthy phenotypes. Methods from evolutionary biology (phylogenetic analysis, comparative method) used to address medically important problems. Realization of range of variation in pathology. Evolution and cancer. Hallmarks of cancer and relationship to evolution of multicellularity. Transmissable tumours in dogs and Tansmanian devils. Moving away from single therapy. Curing versus managing disease. Discussion led by invited professor Thiago Lopes Carvalho (Champalimaud).