Intracellular protein degradation/Folding and human disease
12 Dezembro 2022, 11:00 • Carlos Miguel Ribeiro da Silva Farinha
Intracellular protein degradation
§ The lysosome
§ Autophagy
§ Protein ubiquitination
§ The proteasome: structure and mechanism of action
§ Ubiquitin-like proteins and protein sumoylation
Folding and human disease
§ Misfolding and aggregation
§ Aggregation, aging and life-style
§ Misfolded proteins as infectious agents
§ Folding, UPR and cancer
§ Misfolding and dysfunction by absence
§ Cystic Fibrosis – CFTR Folding and Trafficking