prediction of 3D structure from sequence

17 Outubro 2022, 11:00 • António Eduardo do Nascimento Ferreira

The prediction of protein structure (3D) from sequence: a difficult problem in structural biology. The CASP competition. Homology modelling: concept, stages and tools. The quality of the obtained models. Errors and limitations of the results of homology modelling. The portal SwissModel. Template search, modelling and final optimization by empirical force fields. Other methods of structure prediction: the Rosetta fragment approach. The Alphafold method.