Aula 3.4

13 Dezembro 2021, 11:00 • Carlos Miguel Ribeiro da Silva Farinha

 

Intracellular protein degradation. The lysosome. Autophagy. Protein ubiquitination. The proteasome: structure and mechanism of action. Ubiquitin-like proteins and protein sumoylation. 

Folding and human disease. Misfolding and aggregation. Aggregation, aging and life-style. Misfolded proteins as infectious agents. Folding, UPR and cancer. Misfolding and dysfunction by absence. Cystic Fibrosis– CFTR Folding and Trafficking.