Sumários

Comparative Immunology

18 Dezembro 2019, 15:00 Mark Stephen Gibson

Female Anglerfish; Sexual parasitism in Anglerfish (tissue rejection, MHC, TCR); How do Anglerfish avoid immune rejection, and its relevance to humans; what is Comparative Immunology; Why do we continue to study model/ non-model organisms; Comparative Immunology has been important for centuries; Comparative Immunology: variations and examples: a) Chicken major histocompatibility complex (MHC), b) Comparisons within a species: understand and modulate immune function in those animals, c) Transmission of avian influenza in ferrets, d) Identifying immune mechanisms we can adapt & use in other (experimental) systems.


Immunometabolism

23 Outubro 2019, 15:00 Mark Stephen Gibson

Metabolism and Immunity co-dependence; Signals regulating metabolic pathway activity; Mitochondrial dynamics shape immune cell function(s); Six major metabolic pathways; Metabolic pathways in different immune cell types; Glycolysis in macrophages; The TCA cycle in Macrophages; The role of Itaconate in Macrophages; T-cell metabolism; ROS regulate T cell activation, differentiation, and metabolism; HIV-associated metabolic dysregulation influences immunity.


Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

17 Outubro 2019, 15:00 Mark Stephen Gibson

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.  Cell (2019)  177: 1701–1713. Available here: https://www.sciencedirect.com/science/article/pii/S009286741930460X 


ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands

10 Outubro 2019, 15:00 Mark Stephen Gibson

ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands.  J Exp Med (2019)  216 (10): 2231–2241. Available here: https://rupress.org/jem/article-abstract/216/10/2231/120535/ILC3s-integrate-glycolysis-and-mitochondrial?redirectedFrom=fulltext 


Natural Killer Cells

9 Outubro 2019, 15:00 Mark Stephen Gibson

Development and Diversification of the Human NK Cell Lineage; Development of NK (& ILC1) cells at a glance; The biological functions of NK cells; Mechanisms of NK cell cytotoxicity; The regulation of NK cell function; NK cell education models; NK cell receptors and their ligands; NK cell receptor gene complexes; NK cell phenotypic diversity; NK cells and pregnancy; NK-mediated therapies; Tumour immune escape from NK immunosurveillance; Generation of memory NK cells; Exploiting NK cell memory for tumour therapy.