Modulo 2 Microbiologia Humana: estratégias evasivas em macrófagos por patogenos intracelulares: Legionella

21 Março 2023, 14:00 • Elsa Anes

Macrophage evasion strategies of pathogens 

“Why phagocytosis needs not be a degrading experience for Legionella pneumophila and Mycobacterium tuberculosis?”

First part: Legionella An environmental microorganism an accidental human pathogen

History, outbreak reports; Disease, microbiology, virulence determinants

Legionella in the environment: 

biofilms and life cycle; Intracellular features in amoebae: diversion from the endocytic pathway, LVC, OMV

An accidental human pathogen. 

Infection of alveolar macrophagesOverview of the immune response; Infection Control via autophagy and type I and II IFNs; Uncontrolled infection extensive inflammation and infiltrative pneumonia

Second part: Tuberculosis