Módulo 2 Microbiologia Humana: estratégias evasivas em macrófagos por patogenos intracelulares: Mycobacterium tuberculosis

28 Março 2023, 14:00 • Elsa Anes

Macrophage evasion strategies of pathogens 

“Why phagocytosis needs not be a degrading experience for Mycobacterium tuberculosis?”

Second part: Tuberculosis

1.Tuberculosis: an old disease & overview of the infection

2. The Innate Phase: Tuberculosis & the art of macrophage manipulation. Phagosome maturation blockade by M. tuberculosis. The innate granuloma 

3. The Latent Phase: adaptive granuloma & the art to survive to a robust immune response

4. Primo-infection Vs reactivation: The caveating granuloma & The art to induce strong inflammation

5. Control through programmed cell death and inflammation:Inflammasome activation by Koch’s bacilli

6. Concluding remarks: implications for therapeutic approaches