Módulo 2 Microbiologia Humana:Estratégias invasivas de enteropatogenos

14 Março 2023, 14:00 • Elsa Anes

Invasive strategies of enteropathogens: invading the epithelia  

• Invading epithelial cells: Listeria, Yersinia, Shigella and Salmonella
• Intracellular pathogens: internalization step in epithelia an invasive process
• The actin Cytoskeleton was the first target investigated during Listeria infection. Microfilaments and cell-to-cell junctions.
• Listeria the first multifactorial model: internalization, endosomal escape, actin comets, autophagy and mitochondria fragmentation
• Yersinia and invasive phagocytosis in epithelia and impairment the phagocytic capacities of macrophages/cell death. T3SS and YOPs. Differences  of enteropathogenic Yersinia spp with Y. pestis
• Macropinocytic internalization of Shigella and Salmonella. T3SS.
• Shigella virulence determinants, intracellular trafficking, escape to autophagy and local inflammation.
• Salmonella SPI-1 and 2, invasion and establishment of intracellular niches. Overcoming microbiota and the inflammatory response. Differences between typhoid and non typhoid serovars.