Sumários

Módulo Microbiologia Humana: Os morcegos como animais hospedeiros de múltiplos vírus patogénicos para o Homem: exemplo do vírus Ebola

8 Maio 2025, 10:00 • Elsa Anes

Os morcegos como animais hospedeiros de múltiplos vírus patogénicos para o Homem: exemplo do vírus Ebola
  1. Bats a unique viral reservoir
  2. Tolerance vs resistance
  3. Bats and DNA viruses
  4. Bats and RNA viruses
  5. Bats immunometabolism, episodic spillovers and adaptive immune responses

Vírus Ebola 
  1. Origin, transmission, outbreaks and signs and symptoms, cytokine storm
  2. Viral virulence factors and innate/adaptive immune evasion mechanisms 
  3. The hemorrhagic shock
  4. Future therapies


Módulo Microbiologia Humana: Microrganismos na saúde e na doença: barreiras à invasão, microbiota e disbiose

6 Maio 2025, 10:00 • Elsa Anes

Microrganismos na saúde e na doença: barreiras à invasão, microbiota e disbiose 


Surface barriers and mucosa immunity mechanisms

Complement

External barriers and innate mechanisms

Mucosae: metaplasia cells; mucins; tight junctionsand barrier disruption, microbiota, innate lymphoid cells, intraepithelial lymphocytes

Professional phagocytes

1  neutrophils (NETs) .

2  macrophages; the endocytic pathway and the microbicidal effectors, distinct activating states

3 Dendritic cells from phagocytes to antigen presenting cells.  


Microorganisms in health and disease: 

Microbiota in homeostasis and dysbiosis during infections. Relation with ILC, intraepithelial lymphocytes Th17 and T-Regs. Aryl hydrocarbon receptor one exposome for microbiota and ambiental food and molecules. Role of Serum amyloid A in inflammatory diseases dependent on Il-17.

Non-Celiac diseases, microbiota, dysbiosis, food supplementation, herbicides

Módulo Microbiologia Humana: mecanismos de imunidade inata e adaptativa

29 Abril 2025, 10:00 • Elsa Anes

Innate Immunity:
 a common end for different strategies

Host-pathogen interactions and innate immune responses


What is immunology: from cell autonomous immunity to innate & adaptive responses

The innate immunity inducers and sensors. PAMPS & DAMPS. Families of PRRs: Soluble receptors-Complement; integral protein receptors-TLRs, cytosolic DNA and RNA receptors and the sequestosome.

 TLR signaling in the epithelia and mucosa. Mediators and effectors of innate immunity sensors: cells and secretion of antimicrobial peptides.

NF-KB induced pro-inflammatory cytokines (TNFα, IL1β, IL-6, IL-12, IL-18, Il-33). Type II interferon IFNγ.

IRF induced antiviral response: type I and III interferons. Cytosolic receptors for sensing intracellular pathogens: NLRs, RNA sensors, DNA sensors. Response via inflammasomes. The antiviral response via STING, MAVS.

Programmed cell death as a mechanism of cell autonomous immunity


Avaliação

15 Abril 2025, 10:00 • Mónica Vieira Cunha

Avaliação periódica  - Teste escrito (avaliação das componentes teórica e teórico-prática)

MSP_Módulo One Health_Fungos prioritários em saúde pública

8 Abril 2025, 10:00 • Mónica Vieira Cunha

Impacto global das doenças de etiologia fúngica e fungos prioritários em saúde pública. Desafios atuais. Análise de documentos da OMS. Trabalho em grupo na aula para caracterizar a relevância clínica, epidemiologia e desafios dos vários fungos de prioridade crítica, elevada e média.