Sumários
Huntington Disease and poly Q diseases
29 Novembro 2023, 10:00 • Cláudio Emanuel Moreira Gomes
Huntington Disease and poly Q diseases. Doença de Huntington e doenças Poly-Q– introdução, aspectos genéticos e moleculares. Proteostasis of trinucleotide repeat disorders, chaperões, modelos da Doença de Huntington. Aula convidada pelo Prof. Federico Herrera (FCUL)
Spinal Muscular Atrophy
22 Novembro 2023, 12:00 • Margarida Henriques da Gama Carvalho
Research seminar: Why do motor neurons die?
RNA in Neurodegeneration
15 Novembro 2023, 12:00 • Margarida Henriques da Gama Carvalho
Hands on: One minute paper reviews on the role of RNA metabolism/RNA binding proteins in neurodegeneration and Amyotrophic Lateral Sclerosis: clinical, genetic and mechanistic features
RNA in Neurodegeneration
15 Novembro 2023, 10:00 • Margarida Henriques da Gama Carvalho
An overview of RNA metabolism: interconnectivity, cis and trans regulators, role of RNA binding proteins and phase separation processes.
RNA metabolism and neurodegeneration – connections and functional significance
Main characteristics of ALS – symptoms, presentation, genetics
Neuropathology of ALS – a protein aggregation disease?
Structural characteristics of ALS-associated proteins – Prion like domains as a theme