Genetics in Neurodegeneration

8 Novembro 2023, 12:00 • Margarida Henriques da Gama Carvalho

Hands-on: mind map of the role of genetics in Neurodegeneration

Genetics in Neurodegeneration

8 Novembro 2023, 10:00 • Margarida Henriques da Gama Carvalho

Correlation and Causation in Science – how do we prove an observed event is causal?

Reviewing the principles of genetics: from genotype to phenotype. Monogenic and Polygenic traits in humans.

Defining disease and the genetic basis of disease in the post-genomic era.

Familial vs sporadic cases; germinal vs somatic mutations

Types and mechanisms of mutation. Aging and DNA damage. Transposons.

Gain and loss of function and connection to hereditary transmission patterns.

Somatic mutations in neurodegeneration.

Non-mendelian heredity and role of epigenetics.

Doença de Parkinson

25 Outubro 2023, 12:00 • Cláudio Emanuel Moreira Gomes

Doença de Parkinson (cont). Processos celulares da patogénese em PD. Biomarcadores e possíveis alvos terapêuticos.  Conteúdos Frontier Topics Journal club

Doença de Parkinson

25 Outubro 2023, 10:00 • Cláudio Emanuel Moreira Gomes

Doença de Alzheimer - Terapias e Biomarcadores

18 Outubro 2023, 12:00 • Cláudio Emanuel Moreira Gomes

Biomarcadores na doença de Alzheimer - desenvolvimento, biomarcadores baseados em imagem, fluidos. O papel dos biomarcadores no desenvolvimento de fármacos. Conteúdos Frontier Topics Journal club