Discussão de artigos

20 Outubro 2025, 09:30 • António Eduardo do Nascimento Ferreira

Discussão de artigos.

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Protein Folding: Fundamental Concepts and Thermodynamics.

13 Outubro 2025, 11:00 • Bárbara Joana de Almeida Henriques

Protein Folding, structure and dynamics. Overview of the Structural Diversity of Proteins. Protein Folding Problem: Historical Perspective and Current Challenges. Proteins as Dynamic Entities: Dynamics and Flexibility of Protein Conformation. Anfinsen's Experiment and the Thermodynamic Hypothesis. Definition of Native and Unfolded States. Physical Driving Forces for protein folding and stability. Hydrophobic Effect and Its Interpretation. Influence of Extrinsic Factors (Cofactors, Post-translational Modifications, and Disulfide Bridges).

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Apresentação dos artigos 1.3. e 1.4

13 Outubro 2025, 09:30 • António Eduardo do Nascimento Ferreira

Apresentação dos artigos 1.3. e 1.4.

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Discussão de artigos. Preparação das apresentações

13 Outubro 2025, 09:30 • Carlos Miguel Ribeiro da Silva Farinha

Discussão de artigos. Preparação das apresentações.

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Prediction of protein structure from sequence

6 Outubro 2025, 11:00 • António Eduardo do Nascimento Ferreira

The prediction of protein structure (3D) from sequence: a difficult problem in structural biology. The CASP competition. Homology modelling: concept, stages and tools. The quality of the obtained models. Errors and limitations of the results of homology modelling. The portal SwissModel. Template search, modelling and final optimization by empirical force fields. Other methods of structure prediction: the Rosetta fragment approach. The Alphafold method.

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