Sumários
Protein Misfolding and Aggregation
6 Novembro 2023, 11:00 • Cláudio Emanuel Moreira Gomes
Protein Misfolding and Aggregation. Misfolding
and Brief Overview of the Biological Regulation of the Folding Process:
Cotranslational Folding, Use of Rare Codons, and Chaperone-Catalyzed Folding.
Protein Aggregation. Factors Promoting Protein Aggregation. Inclusion Bodies.
Effect of Solvents (Compatible Solutes) and Small Molecules (Chemical and
Pharmacological Chaperones) in Correcting Protein Misfolding.
Apresentação de artigos
6 Novembro 2023, 09:30 • Cláudio Emanuel Moreira Gomes
Discussão de artigos. Preparação das apresentações.
6 Novembro 2023, 09:30 • Bárbara Joana de Almeida Henriques
Discussão de artigos. Preparação das
apresentações.
Protein Stability and Folding Kinetics.
30 Outubro 2023, 11:00 • Cláudio Emanuel Moreira Gomes
Protein Stability and Folding Kinetics.
Chemical Bonds Involved in Protein Stability and Their Magnitudes. Hydrophobic
Effect and Its Interpretation. Influence of Extrinsic Factors (Cofactors,
Post-translational Modifications, and Disulfide Bridges). Determination of
Protein Stability. Cooperativity of Protein Folding Reaction. Denaturants and
Their Mode of Action. Chemical and Thermal Denaturation Curves. Linear
Extrapolation Method and the Significance of the m Value. Thermal Denaturation.
Apresentação dos artigos.
30 Outubro 2023, 09:30 • Bárbara Joana de Almeida Henriques
Apresentação dos artigos 2.1. e 2.2.