Allergy a type I (or immmediate) hypersensitivity reaction.

21 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Allergy a type I (or immmediate) hypersensitivity reaction. Allergy: a type I hypersensitivity reaction. Common allergens associated with type I hypersensitivity. Allergies stages: sensitization phase. Allergies stages: effector phase. Sequence in events in type I hypersensitivity – sensitization. Sequence in events in type I hypersensitivity – effector phase. Sensitization stage of allergy: Epithelial cells are upstream of the Th2 cell cascade, Epithelial cells and DCs crosstalk control Th2 cell responses in the lung, Allergy: cross-linking of Fcε receptors. Allergies – effector phase: Allergy: IgE receptor signaling is tightly regulated. Mast cell activation and mediators: histamine, leukotrienes and prostaglandins, cytokines and chemokines. The wheal-and-flare reaction in the skin and allergy skin tests. Allergies – the late-phase reaction. Asthma. Airways remodeling. Mediators and treatment of asthma. Allergies: diagnostic tests. Desensitization immunotherapy. Genetic and environmental basis. Loci with greater susceptibility to asthma.