Sumários
Apresentação e discussão do artigo científico
13 Dezembro 2018, 15:00 • Maria Margarida Blasques Telhada
Apresentação e discussão do artigo científico:
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 2016, 167: 1
The immune response to cancer
13 Dezembro 2018, 14:00 • Maria Margarida Blasques Telhada
The immune response to cancer. Immunoediting. cancer-immunologic pathways mediating tumor eradication. CTLs response against tumors. cancer-inflammatory responses promote cancer. Evasion of immune recognition: reduced MHC expression, tumor cell resistance to apoptotic signals, poor costimulatory signals. Cancer immunotherapy: monoclonal antibodies approved by the FDA and licensed for cancer treatment, dendritic cell vaccines, adoptively transferred autologous DCs, TIL transferred cells, CAR T cells, blocking T cell inhibitory pathways, checkpoint blockade therapy.
Cancer and the immune system.
12 Dezembro 2018, 15:00 • Maria Margarida Blasques Telhada
Cancer and the immune system. Terminology and common types of cancer. Malignant transformation of cells. Common human infectious carcinogens. DNA alterations can induce malignant transformation. Genes associated with cancer control cell proliferation and survival. Functional classification of cancer-associated genes. Malignant transformation of cells. Sequential genetic alterations leading to metastic colon cancer. Six fundamental characteristics of the tumor cell - Hanahan e Weinberg 2000. Emerging features of the tumor cell - Hanahan e Weinberg 2011. Tumor antigens. Tumor specific antigens. Tumor-associated antigens.
Apresentação e discussão do artigo científico
6 Dezembro 2018, 15:00 • Maria Margarida Blasques Telhada
Apresentação e discussão do artigo científico:
Critical Role for theMicrobiota in CX3CR1 Intestinal Mononuclear phagocyte Regulation of Intestinal. Immunity 2018, 49: 1