The immune response to cancer

13 Dezembro 2018, 14:00 • Maria Margarida Blasques Telhada

The immune response to cancer. Immunoediting. cancer-immunologic pathways mediating tumor eradication. CTLs response against tumors. cancer-inflammatory responses promote cancer. Evasion of immune recognition: reduced MHC expression, tumor cell resistance to apoptotic signals, poor costimulatory signals. Cancer immunotherapy: monoclonal antibodies approved by the FDA and licensed for cancer treatment, dendritic cell vaccines, adoptively transferred autologous DCs, TIL transferred cells, CAR T cells, blocking T cell inhibitory pathways, checkpoint blockade therapy.