Apresentação e discussão do artigo científico:

25 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Activation of Gpr109a, Receptor for Niacin and the Commensal metabolite Butyrate, Suppresses Colonic Inflammation and carcinogenesis. Immunity 2014, 40: 128.

Intestinal epithelial cells.

25 Outubro 2018, 14:00 • Maria Margarida Blasques Telhada

Intestinal epithelial cells. Several agents in the intestine mucosa. Intestinal mucosa. The cell fate and function of intestinal epithelial componentes. Epithelial cells as an innate immune system component. Microbial recognition is integrated by IECs. IECs and leukocytes recruitment. IECs and PRRs. Goblet cells. Goblet cells products. Paneth cells. AMPs produced by the Paneth cells. Paneth cells – defensins. Paneth cells – Reg proteins. Paneth cells – lysozyme. Paneth cells – PLA2. Enteroendocrine cells. Tuft cells. Intestinal M cells. M cells originate from Lgr5⁺ epithelial stem cells. Intestinal M cells – entry site for pathogens. Intestinal M cells – reverse transcytosis.

Barrier immunity.

24 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Barrier immunity. The mucosal associated lymphoid tissues and the skin. Location of the mucosal immune system in man. Lymph nodes serving mucosal tissues. Mucosal imune system characteristics. Inducing and effector mucosal sites. MALT – inducing mucosal sites. GALT. Composition and load of microbiota in different anatomical sites of the GI. In a healthy human the composition of the microbiota varies on the different mucosal surfaces. Small and large intestine mucosa. Small intestine epithelium. Peyer’s patches. Isolated lymphoid follicles. The barrier function of the epitelium. Factors contributing to the barrier function of the epithelium. Factors contributing to the barrier function of the epithelium – tight junctions. Intercellular junction regulation. Glycocalix. Mucus. Mucins. Mucin functions. The organization of epithelium and mucus in the gastrointestinal tract. a- and b-defensins. Human IgAs. IgA transport to intestinal lumen. The gut immune system maintains a barrier between microbiome and epithelium.

Apresentação e discussão do artigo científico

18 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013, 504: 451.

Immunology of maternal-fetal interface

18 Outubro 2018, 14:00 • Maria Margarida Blasques Telhada

Immunology of maternal-fetal interface. Uterine mucosa during pregnancy. Seminal fluid-induced inflammation in cervix. Immune cells in early human embryo implantation. Cells at maternal–fetal interface during early pregnancy. Decidual DCs. The role of dendritic cells in blastocyst implantation. Decidual macrophages. Treg in mouse pregnancy. Treg cells in human pregnancy – pathology. Immune cells in early embryo implantation. Human decidual NK cells. The immunology of the decidua basalis during pregnancy. Trophoblast-mediated immune regulation. The interactions between the innate and adaptive immune system in human decidua. The three immunological stages of pregnancy.