Immunology of maternal-fetal interface.

17 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Immunology of maternal-fetal interface. Uterine mucosa in non-pregnant state. Menstrual cycle. Deciduation. Blastocyst formation and uterine implantation. Hemochorial placentation. The spiral artery transformation that support early human placental development. Human placenta. The spiral artery transformation that support early human placental development. Uterine mucosa in non-pregnant state. Human vaginal mucosa in non-pregnant state. Human cervix mucosa in non-pregnant state. Uterine mucosa in non-pregnant state.

Apresentação e discussão do artigo científico:

11 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit. Nature 2016, 549: 221.

NK cells.

11 Outubro 2018, 14:00 • Maria Margarida Blasques Telhada

NK cells. Development of NK cells..Physiological NK cell functions. NK receptors and their ligands. Acquisition of natural killer cell function. NK cell subsets. Human NK Cell phenotypic diversity. Adaptative NK cells. Pathways for the generation of memory NK cells. Magnitude and kinetics of CD8+ T cell and NK cell memory formation after infection. Potential applications of memory NK cells for tumour therapy.

The immune system as a sensor of metabolic state

10 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

The immune system as a sensor of metabolic state. Metabolic state. OBESITY. Chronic over-nutrition. Anatomical sites of brown, white and beige adipocytes in mice and humans. White, beige, and brown adipocytes are developmentally and functionally distinct cell populations. Healthy white adipose tissue is enriched in type 2 cytokine-associated immune cells. Healthy white adipose tissue is enriched in AAMac. Healthy white adipose tissue is enriched in ILC2s, iNKT. Cellular changes in adipose tissue in young and aged mice. Nonredundant actions of iNKT and gdT cells promote adipose tissue homeostasis. Healthy white adipose tissue is enriched in type 2 cytokine-associated immune cells. Immune cells in obese WAT are characterized by pro-inflammatory phenotype. Obese white adipose tissue is characterized by type 1 cytokine-associated immune responses. Obesity induces inflammation in adipose tissue, liver, skeletal muscle and pancreas and cause dysbiosis in the intestine. Immune-directed anti-obesity therapies. Tissue-resident leukocytes augment beige adipose tissue development and function in subcutaneous white adipose tissue.

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4 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Interleukin-22 promotes intestinal-stem-cell-mediated epitelial regeneration . Nature 2015, 528: 560