Lamina propria lymphocytes

14 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Lamina propria lymphocytes. The generation and distribution of peripherally FoxP3+pTreg. The generation and distribution of peripherally FoxP3+ RORgt- pTreg. Intestinal lamina propria Th17 cells. The regionalized generation and distribution of IgA+ PCs. The T cell-independent generation of IgA+ PCs. Potential functions of IgA antibodies.

Apresentação e discussão do artigo científico

8 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis.  Cell 2015, 160:74.

Intestinal intraepithelia lymphocytes

8 Novembro 2018, 14:00 • Maria Margarida Blasques Telhada

Intestinal intraepithelial and lamina propria lymphocytes. Intraepithelial lymphocytes – IEL. Induced (type a) intraepithelial lymphocytes. Induced (type a) intraepithelial lymphocytes TCRab+ CD4+CD8aa+. Induced (type a) intraepithelial lymphocytes TCRab+ CD8ab+ . Regulation of type a IELs composition along the length of the intestine. Natural (type b) intraepithelial lymphocytes. Natural (type b) IELs TCRab+CD8aa+ . Natural (type b) intraepithelial lymphocytes TCRgd+CD8aa+ . Intestinal natural (type b) intraepithelial lymphocytes homeostasis. Natural (type b) intraepithelial lymphocytes TCRgd+CD8aa+ in colitis and celiac disease. Development, effector properties, and functions of IELs.

Intestinal macrophages.

7 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Intestinal macrophages. Heterogeneity of tissue-resident macrophage ontogeny in adult tissues in the steady state. Intestinal macrophages in health. Role of LP macrophages in intestinal homeostasis. The intestinal macrophages are phagocytic and anti-inflammatory cells. Intestinal macrophages contribute to oral tolerance. Intestinal macrophages in inflammation.

Dendritic cells

31 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Dendritic cells. The DC subsets. Conventional DCs. Plasmacytoid dendritic cells. Epidermal Langerhans cells. Stages and transcription factors for DC development. Macrophages, IRF8⁺, IRF4⁺ and Langerhans cells in mouse tissues. Correspondence between murine and human DC subsets. Functions of dendritic cell subsets in the immune response. Functions of cDC1 in the immune response. Dendritic cell subsets serve distinct immune effector modules. Intestinal dendritic cells. Dendritic cell subsets in the mouse and human intestinal lamina propria. Murine intestinal CD103⁺ CD11b^- cDC. Murine intestinal CD103⁺ CD11b⁺  cDCs. Murine intestinal CD103^- CD11b⁺  cDCs. Functions of intestinal dendritic cell subsets. Functions of DC in homeostasis – resident T cells formation. Functions of DC in homeostasis -  iTreg and oral tolerance induction. cDC functions in the small intestine LP. cDC functions in the intestinal lymph nodes.