Apresentação e discussão do artigo científico

22 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature 2017, 549: 282

Antibody-mediated (type II) hypersensitivity reactions

22 Novembro 2018, 14:00 • Maria Margarida Blasques Telhada

Antibody-mediated (type II) hypersensitivity reactions. Transfusion reactions. Hemolytic disease of the newborn. Penicillin-induced hypersensitivity reactions. Immune complex-mediated (type III) hypersensitivity reactions. Examples of conditions involving type III hypersensitivity reactions: autoimmune diseases, drug reactions and infectious diseases. Delayed-type (type IV) hypersensitivity (DTH). Intracellular pathogens and contact antigens that induce delayed-type (type IV) hypersensitivity. Sensitization phase. Effector phase. Granuloma. Contact dermatitis.

Allergy a type I (or immmediate) hypersensitivity reaction.

21 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Allergy a type I (or immmediate) hypersensitivity reaction. Allergy: a type I hypersensitivity reaction. Common allergens associated with type I hypersensitivity. Allergies stages: sensitization phase. Allergies stages: effector phase. Sequence in events in type I hypersensitivity – sensitization. Sequence in events in type I hypersensitivity – effector phase. Sensitization stage of allergy: Epithelial cells are upstream of the Th2 cell cascade, Epithelial cells and DCs crosstalk control Th2 cell responses in the lung, Allergy: cross-linking of Fcε receptors. Allergies – effector phase: Allergy: IgE receptor signaling is tightly regulated. Mast cell activation and mediators: histamine, leukotrienes and prostaglandins, cytokines and chemokines. The wheal-and-flare reaction in the skin and allergy skin tests. Allergies – the late-phase reaction. Asthma. Airways remodeling. Mediators and treatment of asthma. Allergies: diagnostic tests. Desensitization immunotherapy. Genetic and environmental basis. Loci with greater susceptibility to asthma.

Apresentação e discussão do artigo científico

15 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature 2016, 535: 440.

Microbiota and the immune system

15 Novembro 2018, 14:00 • Maria Margarida Blasques Telhada

Microbiota and the immune system. Microbiota communities in the intestinal tract. Microbiota communities in differente locations. Spatial distribution and composition of the microbiota along the intestinal tract. Composition of intestinal microbiota varies with diet. The organogenesis of lymphoid tissues. The development of PPs follows a multi-step process of immune-cell and stromal-cell interactions. Common regulatory mechanisms of neuronal and lymphoid organogenesis in the gut. Microbiota metabolites and homeostasis. Immune homeostasis and microbiota metabolites. SCFAs and host immunity.