Sumários
ILCs in tissue remodeling and repair
4 Outubro 2018, 14:00 • Maria Margarida Blasques Telhada
ILCs in tissue remodeling and repair. ILC2s promote the resolution of inflammation and tissue repair. ILC2s tissue repair and tissue remodeling for helminth expulsion. ILC2s promote the resolution of inflammation and tissue repair. ILC3s promote the resolution of inflammation and tissue repair. ILCs and the nervous system. The innate lympoid cells and chronic inflammation. ILC2s and human chronic inflammation diseases. ILC2s and asthma. ILC2s and atopic dermatitis. ILC3s can promote lung chronic inflammation. ILC3s can promote skin chronic inflammation. ILCs limit chronic inflammation. ILC3s can limit chronic inflammation by regulating innate and adaptive immune responses in the intestine. ILCs and chronic intestinal inflammation – Crohn’s disease.
Innate lymphoid cells.
3 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada
Innate lymphoid cells. Group 1 ILC (ILC1s). Group 2 ILC (ILC2s). Group 3 ILC: ILC3s. ILC1s development. ILCs functions. ILC1s and NK cells functions. ILC2s functions. ILC3s functions. Development of lymphoid tissue inducer (LTi)-dependent secondary lymphoid organs (SLO: LN and PP). ILC plasticity. Innate and adaptative lymphoid cells subsets. Innate lymphoid cells in acute inflammation. ILC1s promote acute inflammation and innate immunity to intracellular pathogens in the intestine. ILC2s promote acute inflammation and innate immunity to extracellular parasites in the intestine. ILC3s promote acute inflammation and innate immunity to extracellular microorganisms in the intestine. Innate lymphoid cells in tissue repair.
Distribuição dos alunos por grupos e datas de apresentação dos artigos a analisar.
27 Setembro 2018, 15:00 • Maria Margarida Blasques Telhada
Distribuição dos alunos por grupos e datas de apresentação dos artigos a analisar.
The Adaptive Immune Response in Space and Time.
27 Setembro 2018, 14:00 • Maria Margarida Blasques Telhada
The Adaptive Immune Response in Space and Time. CD8+ T cell activation in the lymph node. The formation of a tricellular complex in a lymph node during CD8+ T cell activation. Activated lymphocytes exit the lymph node and recirculate. Nature and timing of events during T and B cell activation in a lymph node after introduction of antigen. The immune response contracts within 10 to 14 days The contraction of an immune response. Immune cell behavior in peripheral tissues. Activated lymphocytes exit the lymph node and recirculate through various tissues. T Cell Migration Patterns. CD4+ T cells alter the expression of adhesion molecules when they differentiate into effector cells. Effector and memory lymphocytes leave the lymph node via efferent lymphatics and circulate to sites of infection. Signals for Trm cell precursors to enter the gut. Signals for Trm cell precursors to enter the skin. Retention of Trm CD4 + and Trm CD8 + cells in the skin. Circulating and tissue-resident lymphocytes. Where memory T cells can be found.
The Adaptive Immune Response in Space and Time
26 Setembro 2018, 15:00 • Maria Margarida Blasques Telhada
The Adaptive Immune Response in Space and Time. Immune cell behaviour before meeting antigen. Lymphocyte recirculation routes. Naïve lymphocytes circulate between secondary/tertiary lymphoid tissues. Lymphocyte migration through HEV. Extravasation is driven by sequential activation of surface molecules. Steps of leukocyte extravasation. Families of cell-adhesion molecules (CAMs). Lymphocyte migration in the spleen. Naïve lymphocytes browse for antigen along reticular networks in the lymph node. Antigen-presenting cells are present in all lymph node microenvironments. Lymphocytes leave the lymph node through portals in the cortical and medullary sinuses. Immune cell behaviour during the innate immune responses. Innate immune cells are activated by antigen binding to PRRs. Neutrophils and monocytes migrate to a site of inflammation. How antigen travels into a lymph node. Migration of antigen-presenting cells from tissue to lymph node through efferent lymphatics. Antigen entry to lymph node. Immune cell behaviour during the adaptive immune responses. Activation of CD4+ T cells and B cells in a lymph node during a primary immune responses. B cell activity in the germinal center.