The Adaptive Immune Response in Space and Time.

27 Setembro 2018, 14:00 • Maria Margarida Blasques Telhada

The Adaptive Immune Response in Space and Time. CD8+ T cell activation in the lymph node. The formation of a tricellular complex in a lymph node during CD8+ T cell activation. Activated lymphocytes exit the lymph node and recirculate. Nature and timing of events during T and B cell activation in a lymph node after introduction of antigen. The immune response contracts within 10 to 14 days The contraction of an immune response.  Immune cell behavior in peripheral tissues. Activated lymphocytes exit the lymph node and recirculate through various tissues. T Cell Migration Patterns. CD4+ T cells alter the expression of adhesion molecules when they differentiate into effector cells. Effector and memory lymphocytes leave the lymph node via efferent lymphatics and circulate to sites of infection. Signals for Trm cell precursors to enter the gut. Signals for Trm cell precursors to enter the skin. Retention of Trm CD4 + and Trm CD8 + cells in the skin. Circulating and tissue-resident lymphocytes. Where memory T cells can be found.