The Adaptive Immune Response in Space and Time

26 Setembro 2018, 15:00 • Maria Margarida Blasques Telhada

The Adaptive Immune Response in Space and Time. Immune cell behaviour before meeting antigen. Lymphocyte recirculation routes. Naïve lymphocytes circulate between secondary/tertiary lymphoid tissues. Lymphocyte migration through HEV. Extravasation is driven by sequential activation of surface molecules. Steps of leukocyte extravasation. Families of cell-adhesion molecules (CAMs). Lymphocyte migration in the spleen. Naïve lymphocytes browse for antigen along reticular networks in the lymph node. Antigen-presenting cells are present in all lymph node microenvironments. Lymphocytes leave the lymph node through portals in the cortical and medullary sinuses. Immune cell behaviour during the innate immune responses. Innate immune cells are activated by antigen binding to PRRs. Neutrophils and monocytes migrate to a site of inflammation. How antigen travels into a lymph node. Migration of antigen-presenting cells from tissue to lymph node through efferent lymphatics. Antigen entry to lymph node. Immune cell behaviour during the adaptive immune responses. Activation of CD4+ T cells and B cells in a lymph node during a primary immune responses. B cell activity  in the germinal center.