Primary immunodeficiencies.

6 Dezembro 2018, 14:00 • Maria Margarida Blasques Telhada

Primary immunodeficiencies. Primary immunodeficiencies due to defects in innate immune responses: type 1 leukocyte adhesion deficiency, Chronic granulomatous disease, defects of the IFNg / IL-12 axis, complement deficiencies. Primary immunodeficiencies due to defects in adaptive immune responses. Severe combined immunodeficiencies: - #X linked SCID, SCID Jak3, SCID IL-7Ra, SCID CD45, immunodeficiencies-ADA and PNP defects, SCID RAG, Omnen syndrome, SCID artemis, reticular dysgenesis. Combined immunodeficiencies: MHC expression deficiencies. T-cell specific immunodeficiencies: Defects in TCR signaling. Deficiencies in antibody production. #X-linked agammaglobulinemia (XLA) or Bruton. Agammaglobulinemia non Bruton. Defects in B-cell activation. Selective IgA deficiency. Hyper IgM syndromes.

Transplantation immunology.

5 Dezembro 2018, 15:00 • Maria Margarida Blasques Telhada

Transplantation immunology. Graft rejection occurs based on immunologic principles. T cells are essential for transplant rejection. Molecular bases of allorecognition. Immune recognition of allogeneic MHC molecules. Immunology of solid organ transplants. Minor histocompatibility antigens (MiHA). Examples of minor histocompatibility murine and human antigens. Types of clinical rejection and its mechanisms: hyperacute rejection, acute rejection and chronic rejection. Graft-versus-host disease. Transplantation immunology – therapy generalized immunosuppressive therapy, specific immunosuppressive therapy.

Apresentação e discussão do artigo científico

29 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Apresentação e discussão do artigo científico:

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell 2016, 164: 378.

Autoimmune diseases.

29 Novembro 2018, 14:00 • Maria Margarida Blasques Telhada

Autoimmune diseases. APS-1. IPEX. Hashimoto’s thyroiditis. Graves disease. Multiple sclerosis. Myasthenia gravis. Psoriasis. Type 1 diabetes mellitus. Systemic lupus erythematosus (SLE). Rheumatoid arthritis. Mechanisms underlying autoimmune diseases: inflammation and autoimmunity induced by infection, molecular mimicry of antigens, epitopes expansion. Factors that favor susceptibility to autoimmune disease. Genes that favor susceptibility to autoimmune disease. Environmental factors. Autoimmunity – therapies. Autoimmune diseases can be treated by general or pathway-specific immunosuppression. Drugs currently approved by the FDA or undergoing clinical trials to treat autoimmune disease or suppress the immune response, arranged according to mechanism of action.

Autotolerance and autoimmunity.

28 Novembro 2018, 15:00 • Maria Margarida Blasques Telhada

Autotolerance and autoimmunity. Auto-tolerance mechanisms. Central tolerance. Establishment and maintenance of tolerance. Peripheral tolerance. Antigen sequestration. Autoimmunity. Organ-specific autoimmune diseases in humans. Systemic autoimmune diseases in humans. Experimental animal models of autoimmune diseases.