Barrier immunity.

24 Outubro 2018, 15:00 • Maria Margarida Blasques Telhada

Barrier immunity. The mucosal associated lymphoid tissues and the skin. Location of the mucosal immune system in man. Lymph nodes serving mucosal tissues. Mucosal imune system characteristics. Inducing and effector mucosal sites. MALT – inducing mucosal sites. GALT. Composition and load of microbiota in different anatomical sites of the GI. In a healthy human the composition of the microbiota varies on the different mucosal surfaces. Small and large intestine mucosa. Small intestine epithelium. Peyer’s patches. Isolated lymphoid follicles. The barrier function of the epitelium. Factors contributing to the barrier function of the epithelium. Factors contributing to the barrier function of the epithelium – tight junctions. Intercellular junction regulation. Glycocalix. Mucus. Mucins. Mucin functions. The organization of epithelium and mucus in the gastrointestinal tract. a- and b-defensins. Human IgAs. IgA transport to intestinal lumen. The gut immune system maintains a barrier between microbiome and epithelium.