Autoimmune diseases.

29 Novembro 2018, 14:00 • Maria Margarida Blasques Telhada

Autoimmune diseases. APS-1. IPEX. Hashimoto’s thyroiditis. Graves disease. Multiple sclerosis. Myasthenia gravis. Psoriasis. Type 1 diabetes mellitus. Systemic lupus erythematosus (SLE). Rheumatoid arthritis. Mechanisms underlying autoimmune diseases: inflammation and autoimmunity induced by infection, molecular mimicry of antigens, epitopes expansion. Factors that favor susceptibility to autoimmune disease. Genes that favor susceptibility to autoimmune disease. Environmental factors. Autoimmunity – therapies. Autoimmune diseases can be treated by general or pathway-specific immunosuppression. Drugs currently approved by the FDA or undergoing clinical trials to treat autoimmune disease or suppress the immune response, arranged according to mechanism of action.