Lecture 5: Innate immunity (2ndPart). Microbes in health and disease

23 Março 2020, 17:00 • Elsa Anes

First Part: Surface barriers and phagocytic cells that patrols epithelia. 

1 Phagocytic cells: neutrophils (NETs) .

2 Phagocytic cells: macrophages; the endocytic pathway and the microbicidal effectors

3 Dendritic cells and Innate lymphoid cells.  

4 External barriers and innate mechanisms .

5Mucosae: metaplasia cells; mucins; tight junctions and barrier disruption Surface barriers and phagocytic cells that patrols epithelia 

6 Microorganisms in health and disease: Microbiota in homeostasis and dysbiosis during infections. Relation with ILC, Th17 and T-Regs 

Second Part: Microorganisms in health and disease.

 Endogenous retroviruses, species evolution and acquisition of innate immunity

Mechanisms leading to the endogenization of viral elements into cell genome 

• General characteristics of endogenous viral elements (EVE) 

• Role of endogenous retroviruses (ERV) in human disease 

• Physiologic roles of ERV : Placentation • Muscles fibers • Immune function