Lecture 8: macrophage evasion strategies of pathogens

27 Abril 2020, 17:00 • Elsa Anes

Lecture 8: macrophage evasion strategies of pathogens

“Why phagocytosis needs not be a degrading experience for Legionella pneumophila and Mycobacterium tuberculosis?”

First part: Legionella An environmental microorganism an accidental human pathogen

History, outbreak reports; Disease, microbiology, virulence determinants

Legionella in the environment: biofilms and life cycle; Intracellular features in amoebae: diversion from the endocytic pathway, LVC, OMV

An accidental human pathogen. Infection of alveolar macrophages

Overview of the immune response; Infection Control via autophagy and type I and II IFNs; Uncontrolled infection extensive inflammation and infiltrative pneumonia

Second part: Tuberculosis

1.the disease, overview of the immune response

2. Phagosome maturation blockade by M. tuberculosis

3. Macrophage, DC killing effectors for M. tuberculosis

4. targeting host cathepsins

5. targeting host microRNAs

6. Control through programmed cell death and inflammation:

Inflammasome activation by Koch’s bacilli

7. Concluding remarks: strategies for vaccine development and

Host directed therapies