Lecture 9: Mechanisms of drug resistance
4 Maio 2020, 17:00 • Elsa Anes
Lecture 9: Mechanisms of drug resistance
Antibacterial agents: Mechanisms of action and of resistance
Mechanisms of action:
1) Inhibitors of cell wall synthesis
2) Inhibitors of protein synthesis
3) DNA synthesis inhibitors
4) RNA synthesis inhibitors
Mechanisms of resistance
Intrinsic or inherent resistance
Genetic basis of antimicrobial resistance:
1) drug modification or inactivation
2) Prevention of cellular uptake or efflux
3) Target modification
4) Target overproduction or enzymatic bypass
5) Target mimicry