Macrophage evasion strategies of pathogens
“Why phagocytosis needs not be a degrading experience for Legionella pneumophila and Mycobacterium tuberculosis?”
First part: Legionella An environmental microorganism an accidental human pathogen
History, outbreak reports; Disease, microbiology, virulence determinants
Legionella in the environment:
biofilms and life cycle; Intracellular features in amoebae: diversion from the endocytic pathway, LVC, OMV
An accidental human pathogen.
Infection of alveolar macrophagesOverview of the immune response; Infection Control via autophagy and type I and II IFNs; Uncontrolled infection extensive inflammation and infiltrative pneumonia
Second part: Tuberculosis
1.the disease, overview of the immune response
2. Phagosome maturation blockade by M. tuberculosis
3. targeting host cathepsins
4. targeting host microRNAs
5. Control through programmed cell death and inflammation:
Inflammasome activation by Koch’s bacilli
6. Concluding remarks: strategies for Host directed therapies