Sumários
Tidying up loose ends
21 Dezembro 2016, 16:00 • Christopher David Maycock
Completion of characterisation of products prepared (PL11.2). M.p. and IR spectra.
The endiandric cascade
21 Dezembro 2016, 14:00 • Christopher David Maycock
Molecular orbitals and their visualisation. HOMO and LUMO MOs and their interactions. Cycloadditions and electrocyclic reactions in 4, 6, and 8 pi systems.
Electrocyclisation: Rotatory and disrotatory cyclisations. Synthesis of the endiandric acids using similar intermediates. Reactions and tricks for the selective protection of hydroxyl groups. (Nicolau)
Tidying up loose ends
14 Dezembro 2016, 16:00 • Christopher David Maycock
Completion of characterisation of products prepared (PL11.1). M.p. and IR spectra.
Prostaglandin synthesis (Corey)
14 Dezembro 2016, 14:00 • Christopher David Maycock
[4+2] Cycloaddition of an electron rich diene with electron poor diemophile to form a bicyclo-]2.2.1] system. Endo and exo cycloadditions. Hydrolysis of cyanohydrins to form ketones. Bayer-Villiger oxidation to form lactone. Migratory potential for this reaction not discussed in detail. Iodolactonisation revisited and reduction of halides using tributylstannane and AIBN. Use of Boron halides for the cleavage of methyl ethers. Cr(VI) oxidations with and without water present. Formation of phosphonate esters using halides and trialkylphosphites. Variations on the Wittig reaction using phosphonates. Reduction of lactones to lactols with DIBAL and their reactions with ketophosphonates.
Synthesis of 2-chloro-5-iodopyridine (PL11.2)
7 Dezembro 2016, 16:00 • Christopher David Maycock
Diazotisation of 2-amino-5-iodopyridine using sodium nitrite in HCl.