Some general synthetic methods

2 Novembro 2016, 14:00 • Christopher David Maycock

Synthesis of amines using azides. Protecting groups for hydroxyls (acetate,benzyl, THP) normally to prevent O-nucleophilicity and eliminate the acidity of OH groups. Protecting groups for amines to prevent reactions of the nitrogen atom using carbamates. Deprotection methods. acid hydrolysis of acetals, hydrogenolysis of benzyl groups or benzyl carbamates, acid removal of tet-Bu group from esters and carbamates. Silyl protecting groups and their removal with fluoride. Bulky and less reactive silyl groups for acid and base resistance during functional group and C_C-bond forming reactions.