Sumários
Cystic Fibrosis and protein glycosylation
21 Outubro 2016, 14:00 • Amélia Pilar Grases dos Santos Silva Rauter
Cystic fibrosis and protein glycosylation. The role of N-glycosylation for protein folding in endoplasmic reticulum. O-glycosylation and mucins – tridimensional organization, biological function, formation and cellular maturation, and relevance in respiratory pathologies (invited lecturer: Dr. Carlos Farinha, BioISI, FCUL).
Topics assignment
14 Outubro 2016, 16:00 • Amélia Pilar Grases dos Santos Silva Rauter
Topics for the seminar and written report were assigned and discussed the papers to be used.
Biologically relevant oligosaccharides: Structure and nomenclature.
14 Outubro 2016, 14:00 • Amélia Pilar Grases dos Santos Silva Rauter
Structure of natural glycosides and oligosaccharides. Reducing and non reducing oligosaccharides. Nomenclature and structure of biologically relevant oligosaccharides.
Research on the topic for the seminar
13 Outubro 2016, 15:00 • Amélia Pilar Grases dos Santos Silva Rauter
Searching, reading and discussing papers relevant for the seminar, which topic has been proposed. The following topics were proposed:
Galactins in pregnancy; beta-secretase inhibition and Alzheimer's disease; Glycoredox; Glycosylation and influenza virus; Targets in cancer therapy;
Glut transporters and cancer; glycosylation in cancer; glycolipids and biological membranes.
Structure of monosaccharides (cont.).
10 Outubro 2016, 11:00 • Amélia Pilar Grases dos Santos Silva Rauter
Natural deoxy sugars and amino sugars. Anomeric effect, reverse anomeric effect, exo- and endo-anomeric effects. Configurational reference atom and anomeric reference atom. Naming monosaccharides with more than 4 chirality centers (with the exception of the anomeric carbon). Structure and systematic name of sialic acid.