Cystic Fibrosis and protein glycosylation

21 Outubro 2016, 14:00 • Amélia Pilar Grases dos Santos Silva Rauter

Cystic fibrosis and protein glycosylation. The role of N-glycosylation for protein folding in endoplasmic reticulum. O-glycosylation and mucins – tridimensional organization, biological function, formation and cellular maturation, and relevance in respiratory pathologies (invited lecturer: Dr. Carlos Farinha, BioISI, FCUL).

Topics assignment

14 Outubro 2016, 16:00 • Amélia Pilar Grases dos Santos Silva Rauter

Topics for the seminar and written report were assigned and discussed the papers to be used.

Biologically relevant oligosaccharides: Structure and nomenclature.

14 Outubro 2016, 14:00 • Amélia Pilar Grases dos Santos Silva Rauter

Structure of natural glycosides and oligosaccharides. Reducing and non reducing oligosaccharides. Nomenclature and structure of biologically relevant oligosaccharides.

Research on the topic for the seminar

13 Outubro 2016, 15:00 • Amélia Pilar Grases dos Santos Silva Rauter

Searching, reading and discussing papers relevant for the seminar, which topic has been proposed. The following topics were proposed:

Galactins in pregnancy; beta-secretase inhibition  and Alzheimer's disease; Glycoredox; Glycosylation and influenza virus; Targets in cancer therapy; 

Glut transporters and cancer; glycosylation in cancer; glycolipids and biological membranes.

Structure of monosaccharides (cont.).

10 Outubro 2016, 11:00 • Amélia Pilar Grases dos Santos Silva Rauter

Natural deoxy sugars and amino sugars. Anomeric effect, reverse anomeric effect, exo- and endo-anomeric effects. Configurational reference atom and anomeric reference atom. Naming monosaccharides with more than 4 chirality centers (with the exception of the anomeric carbon). Structure and systematic name of sialic acid.