Sumários

Prediction of protein families and domains

3 Outubro 2022, 11:00 • António Eduardo do Nascimento Ferreira

Demonstration of the application of deterministic patterns on the sequence of a protein using too PROSITE. Classification of proteins into families and the detection of domains from sequences. Multiple sequence alignments as the starting procedure in the classification of new proteins. Position Specific Scoring Matrices and Hidden Markov models as methods of feature prediction from sequences. The assessment of the performance of methods. The InterPro portal as an aggregative tool for family/domain prediction from sequence. Demonstration of the use of InterPro in a multi-domain protein.

Presentation and discussion of papers

3 Outubro 2022, 09:30 • António Eduardo do Nascimento Ferreira

Presentation of papers 1.1 and 1.2

Artigos

3 Outubro 2022, 09:30 • Cláudio Emanuel Moreira Gomes

Discussão de artigos. Preparação das apresentações.

General principles of protein structure and classification. Deterministic patterns.

26 Setembro 2022, 11:00 • António Eduardo do Nascimento Ferreira

General principles about protein structure. Structural levels and representations. Modern view of the central dogma of molecular biology. Definition of domain. Examples. Difference between domain and subunit.

General ideas about the classification of proteins. The scope and general mechanism of the prediction of structural and functional features from a protein sequence. Role of MSAs and the inference of signatures. Introduction to deterministic patterns.

Dicussion of papers

26 Setembro 2022, 09:30 • António Eduardo do Nascimento Ferreira

Dicussion of papers. Preparation of student presentations.