Sumários
Protein Folding diseases
11 Novembro 2024, 11:00 • Cláudio Emanuel Moreira Gomes
Protein Folding diseases - Mechanisms, Classification, and Examples. Amyloid State. Characteristics of the Amyloid State, Mechanisms of Formation. Amyloid State as a Universally Accessible Conformation to Any Polypeptide Chain. Evolutionary Adaptations in Proteins with Anti-Amyloid Effects. Functional and Pathological Amyloids. Amyloids in Neurodegeneration: Amyloid-Beta and Tau in Alzheimer's Disease.
Protein Misfolding and Aggregation
4 Novembro 2024, 11:00 • Cláudio Emanuel Moreira Gomes
Misfolding and Brief Overview of the Biological Regulation of the Folding Process: Cotranslational Folding, Use of Rare Codons, and Chaperone-Catalyzed Folding. Protein Aggregation. Factors Promoting Protein Aggregation. Inclusion Bodies. Effect of Solvents (Compatible Solutes) and Small Molecules (Chemical and Pharmacological Chaperones) in Correcting Protein Misfolding.
Levinthal's Paradox and the Concept of Energy Funnel.
28 Outubro 2024, 11:00 • Cláudio Emanuel Moreira Gomes
Protein Stability and Folding Kinetics. Chemical Bonds Involved in Protein Stability and Their Magnitudes. Hydrophobic Effect and Its Interpretation. Influence of Extrinsic Factors (Cofactors, Post-translational Modifications, and Disulfide Bridges). Determination of Protein Stability. Cooperativity of Protein Folding Reaction. Denaturants and Their Mode of Action. Chemical and Thermal Denaturation Curves. Linear Extrapolation Method and the Significance of the m Value. Thermal Denaturation.
Protein Folding: Fundamental Concepts and Thermodynamics.
21 Outubro 2024, 11:00 • Cláudio Emanuel Moreira Gomes
Structural Diversity of Proteins and Introduction to the Protein Folding Problem. Overview of the Structural Diversity of Proteins. Protein Folding Problem: Historical Perspective and Current Challenges. Proteins as Dynamic Entities: Dynamics and Flexibility of Protein Conformation. Anfinsen's Experiment and the Thermodynamic Hypothesis. Anfinsen's Experiment and the Thermodynamic Hypothesis of the Protein Folding Process. Definition of Native and Unfolded States. Kinetics of Protein Folding Reaction:
Course Presentation
16 Setembro 2024, 11:00 • Cláudio Emanuel Moreira Gomes
Instructors, Syllabus, Bibliography and Assessment/Evaluation