Sumários

Apresentação de artigos

4 Novembro 2024, 09:30 Bárbara Joana de Almeida Henriques

Apresentação de artigos .

Aula lecionada pelo Professor Cláudio M. Gomes.


Levinthal's Paradox and the Concept of Energy Funnel.

28 Outubro 2024, 11:00 Cláudio Emanuel Moreira Gomes

Protein Stability and Folding Kinetics. Chemical Bonds Involved in Protein Stability and Their Magnitudes. Hydrophobic Effect and Its Interpretation. Influence of Extrinsic Factors (Cofactors, Post-translational Modifications, and Disulfide Bridges). Determination of Protein Stability. Cooperativity of Protein Folding Reaction. Denaturants and Their Mode of Action. Chemical and Thermal Denaturation Curves. Linear Extrapolation Method and the Significance of the m Value. Thermal Denaturation.


Apresentação de artigos

28 Outubro 2024, 09:30 Bárbara Joana de Almeida Henriques

Apresentação de artigos.

Aula lecionada pelo Professor Cláudio M. Gomes.


Discussão de artigos. Preparação das apresentações.

28 Outubro 2024, 09:30 Bárbara Joana de Almeida Henriques

Discussão de artigos. Preparação das apresentações.



Protein Folding: Fundamental Concepts and Thermodynamics.

21 Outubro 2024, 11:00 Cláudio Emanuel Moreira Gomes

Structural Diversity of Proteins and Introduction to the Protein Folding Problem. Overview of the Structural Diversity of Proteins. Protein Folding Problem: Historical Perspective and Current Challenges. Proteins as Dynamic Entities: Dynamics and Flexibility of Protein Conformation. Anfinsen's Experiment and the Thermodynamic Hypothesis. Anfinsen's Experiment and the Thermodynamic Hypothesis of the Protein Folding Process. Definition of Native and Unfolded States. Kinetics of Protein Folding Reaction: